Vilazodone

77 interactions 7 explained in plain English
Also sold as: Viibryd
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Vilazodone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Vilazodone Amitriptyline Elavil Explained Increased risk for serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Vilazodone Sertraline Explained Increased risk for serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Vilazodone Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Vilazodone Relugolix Orgovyx Explained Increased relugolix exposure Details Vilazodone Colchicine Colcrys Explained Increased P-gp substrate exposure Details Vilazodone Apixaban Eliquis Explained An increased risk of bleeding Details Vilazodone Aspirin Acuprin® An increased risk of bleeding Details Vilazodone Aspirin Rectal Aspirin An increased risk of bleeding Details Vilazodone Betrixaban Bevyxxa® An increased risk of bleeding Details Vilazodone Anagrelide Agrylin An increased risk of bleeding Details Vilazodone Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Vilazodone Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Vilazodone Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Vilazodone Clopidogrel Plavix An increased risk of bleeding Details Vilazodone Cyclosporine Injection Atopica Increased P-gp substrate exposure Details Vilazodone Cyclosporine Ophthalmic Cequa Increased P-gp substrate exposure Details Vilazodone Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Vilazodone Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Vilazodone Dalteparin Injection Fragmin An increased risk of bleeding Details Vilazodone Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Vilazodone Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Vilazodone Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Vilazodone Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Vilazodone Digoxin Cardoxin® Increased P-gp substrate exposure Details Vilazodone Dipyridamole Permole® An increased risk of bleeding Details Vilazodone Dolasetron Anzemet Increased risk of serotonin syndrome Details Vilazodone Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Vilazodone Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Vilazodone Edoxaban Savaysa An increased risk of bleeding Details Vilazodone Enoxaparin Lovenox An increased risk of bleeding Details Vilazodone Enoxaparin Injection Lovenox An increased risk of bleeding Details Vilazodone Epoprostenol Flolan An increased risk of bleeding Details Vilazodone Etodolac Lodine An increased risk of bleeding Details Vilazodone Everolimus Afinitor Increased P-gp substrate exposure Details Vilazodone Fenoprofen Fenopron An increased risk of bleeding Details Vilazodone Fentanyl Transdermal Patch Duragesic® Increased risk for serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.