Vilazodone and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Vilazodone
Cyclosporine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased P-gp substrate exposure
Interaction Deep Dive
Concomitant use of vilazodone (a P-gp inhibitor) and digoxin, a P-gp substrate, resulted in increased exposure of digoxin. Coadministration of vilazodone (a P-gp inhibitor) and a P-gp substrate with a narrow therapeutic index may increase exposure of the substrate. Measure serum concentrations of the substrate prior to vilazodone use and continue to monitor during coadministration1.
Why it happens (mechanism)
Inhibition of P-gp-mediated efflux transport by vilazodone
Literature reports
1 report — tap to read
a) Coadministration of vilazodone (a P-gp inhibitor) and digoxin (a P-gp substrate) in an drug interaction study resulted in an increase of vilazodone Cmax and AUC by 1- to 1.5-fold approximately 1.
Common questions
Can I take Vilazodone and Cyclosporine Injection together?
Increased P-gp substrate exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Vilazodone and Cyclosporine Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Vilazodone or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: VIIBRYD(R) oral tablets, vilazodone HCl oral tablets. Allergan USA Inc (per FDA), Madison, NJ, 2023. DailyMed
Keep reading about Vilazodone
Keep reading about Cyclosporine Injection
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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