Vilazodone

Name: Vilazodone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

77 interactions 7 explained in plain English

Also sold as: Viibryd

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Metoclopramide Nasal Spray Linezolid Injection Betrixaban Everolimus Hydromorphone Rectal

3 Contraindicated 70 Major 4 Moderate

All (77) Contraindicated (3) Major (70) Moderate (4)

Moderate

Vilazodone Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Vilazodone Dihydroergotamine Injection DHE-45® Injection An increased risk of weakness, hyperreflexia and incoordination Details Vilazodone Dihydroergotamine Nasal Spray Migranal An increased risk of weakness, hyperreflexia and incoordination Details Vilazodone Lumateperone Caplyta An increased risk for serotonin reuptake inhibitor (SRI)-associated adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.