Linezolid Injection and Valbenazine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Linezolid Injection
Valbenazine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased MAOI exposure and an increased risk of serotonin syndrome or attenuated effect of valbenazine
Interaction Deep Dive
Coadministration of valbenazine with an MAOI may increase concentrations of monamines in the neuronal synapse and the risk for adverse effects, including serotonin syndrome. Avoid coadministration of valbenazine with an MAOI or within 14 days of discontinuing therapy with an MAOI1.
Why it happens (mechanism)
Increased concentration of monamines in neuronal synapse
Common questions
Can I take Linezolid Injection and Valbenazine together?
Increased MAOI exposure and an increased risk of serotonin syndrome or attenuated effect of valbenazine Always confirm with your pharmacist or prescriber before making any change.
How serious is the Linezolid Injection and Valbenazine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Linezolid Injection or Valbenazine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: INGREZZA(R) oral capsules, valbenazine oral capsules. Neurocrine Biosciences Inc (per FDA), San Diego, CA, 2023. DailyMed
Keep reading about Linezolid Injection
Keep reading about Valbenazine
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