Bupropion

117 interactions 4 explained in plain English

Also sold as: Aplenzin Aplenzin® Budeprion® SR Budeprion® XL Buproban® Forfivo Forfivo® XL Wellbutrin Wellbutrin® Wellbutrin® SR Wellbutrin® XL Zyban®

About Bupropion

Bupropion is an antidepressant used to treat depression, seasonal affective disorder, and to help people quit smoking. Read the full Bupropion drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Nebivolol Dopamine Famotidine Acyclovir Penicillin V Potassium

1 Contraindicated 114 Major 2 Moderate

All (117) Contraindicated (1) Major (114) Moderate (2)

Major

Bupropion Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Lowering of the seizure threshold Details Bupropion Digoxin Cardoxin® Reduced digoxin exposure Details Bupropion Diphenhydramine Injection Banophen Increased risk of seizures Details Bupropion Diphenhydramine Topical Afterbite with Antihistamine Increased risk of seizures Details Bupropion Disulfiram Antabuse Increased buPROPion exposure and reduced hydroxybuPROPion exposure Details Bupropion Dopamine Reduced renal clearance of OCT2 substrates Details Bupropion Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Bupropion Epinastine Ophthalmic Elestat® Increased risk of seizures Details Bupropion Estradiol Delestrogen Increased risk of seizures Details Bupropion Estradiol Topical Divigel Increased risk of seizures Details Bupropion Estradiol Transdermal Patch Alora® Increased risk of seizures Details Bupropion Estramustine Emcyt Increased risk of seizures Details Bupropion Etomidate Increased risk of seizures Details Bupropion Famotidine Calmicid Reduced renal clearance of OCT2 substrates Details Bupropion Famotidine Injection Calmicid Reduced renal clearance of OCT2 substrates Details Bupropion Fentanyl Transdermal Patch Duragesic® Increased risk of seizures Details Bupropion Flecainide Tambocor® Increased exposure of CYP2D6 substrates Details Bupropion Fludrocortisone Acetate Florinef® Lowering of the seizure threshold Details Bupropion Flunisolide Nasal Spray Nasalide® Lowering of the seizure threshold Details Bupropion Flunisolide Oral Inhalation AeroBid® Inhaler System Lowering of the seizure threshold Details Bupropion Foscarnet Injection Foscavir Increased risk of seizures Details Bupropion Galantamine Razadyne Increased risk of seizures Details Bupropion Ganciclovir Cytovene® Oral Increased risk of seizures Details Bupropion Ganciclovir Injection Cytovene® I.V.® Increased risk of seizures Details Bupropion Ganciclovir Ophthalmic Zirgan Increased risk of seizures Details Bupropion Gatifloxacin Ophthalmic Zymar® Increased risk of seizures Details Bupropion Hydrocortisone Ala-Cort Lowering of the seizure threshold Details Bupropion Hydrocortisone Injection A-Hydrocort® Lowering of the seizure threshold Details Bupropion Hydromorphone Injection Dilaudid Increased risk of seizures Details Bupropion Hydromorphone Rectal available generically Increased risk of seizures Details Bupropion Hydroxychloroquine Plaquenil Increased risk of seizures Details Bupropion Ifosfamide Injection Ifex Increased risk of seizures Details Bupropion Ketotifen Alaway Increased risk of seizures Details Bupropion Ketotifen Ophthalmic Alaway Increased risk of seizures Details Bupropion Levodopa Oral Inhalation Inbrija An increased risk of CNS toxicity (eg., restlessness, agitation, tremor, ataxia, gait problems, vertigo, dizziness) and an increas... Details Bupropion Levofloxacin Levaquin Increased risk of seizures Details Bupropion Levofloxacin Injection Levaquin Increased risk of seizures Details Bupropion Lindane Gamene® Increased risk of seizures Details Bupropion Lithium Carbonate Lithobid Increased risk of seizures Details Bupropion Maprotiline Ludiomil® Increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.