Drug Interaction Report

Bupropion and Levodopa Oral Inhalation: Interaction Details

A pharmacist-reviewed analysis of the Bupropion and Levodopa Oral Inhalation interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Levodopa Oral Inhalation

Inbrija Inbrija®
+

Bupropion

Aplenzin Aplenzin® Budeprion® SR Budeprion® XL Buproban® Forfivo Forfivo® XL Wellbutrin
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
LinkedIn
Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 117 documented Bupropion interactions, 114 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of CNS toxicity (eg., restlessness, agitation, tremor, ataxia, gait problems, vertigo, dizziness) and an increased risk of adverse reactions from accumulative DOPamine agonist effects

Interaction Deep Dive

Use caution with coadministration of buPROPion with levodopa, as CNS toxicity associated with cumulative DOPamine agonist effects has been reported1234.

Why it happens (mechanism)

Additive DOPamine agonist effects

Common questions

Can I take Bupropion and Levodopa Oral Inhalation together?

An increased risk of CNS toxicity (eg., restlessness, agitation, tremor, ataxia, gait problems, vertigo, dizziness) and an increased risk of adverse reactions from accumulative DOPamine agonist effects Always confirm with your pharmacist or prescriber before making any change.

How serious is the Bupropion and Levodopa Oral Inhalation interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Bupropion or Levodopa Oral Inhalation need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (4)

  1. Product Information: WELLBUTRIN XL(R) oral extended-release tablets, bupropion hydrochloride oral extended-release tablets. Bausch Health US, LLC (per FDA), Bridgewater, NJ, 2024. DailyMed
  2. Product Information: WELLBUTRIN(R) SR oral sustained-release tablets, bupropion hydrochloride oral sustained-release tablets. GlaxoSmithKline (per FDA), Durham, NC, 2024. DailyMed
  3. Product Information: WELLBUTRIN(R) oral tablets, bupropion hydrochloride oral tablets. GlaxoSmithKline (per FDA), Durham, NC, 2024. DailyMed
  4. Product Information: FORFIVO XL(R) oral extended-release tablets, bupropion hydrochloride oral extended-release tablets. TWi Pharmaceuticals USA, Inc (per FDA), Paramus, NJ, 2024. DailyMed
Was this write-up helpful?
Levodopa Oral Inhalation

Keep reading about Levodopa Oral Inhalation

All Levodopa Oral Inhalation interactions (208) Levodopa Oral Inhalation drug information
Also serious with: Linezolid Methylene Blue Moclobemide Nialamide
Bupropion

Keep reading about Bupropion

All Bupropion interactions (117) Bupropion drug information
Also serious with: Linezolid Injection Desonide Nebivolol Penicillin V Potassium
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Bupropion + Activated Charcoal Adrafinil African Wild Potato Artichoke Astaxanthin Beer Biofeedback Cannabidiol (cbd) + 38 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.