Buspirone

40 interactions 5 explained in plain English
Also sold as: Bucapsol Buspar
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Buspirone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Buspirone Amitriptyline Elavil Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Buspirone Sertraline Explained An increased risk of serotonin syndrome Details Buspirone Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Buspirone Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Buspirone Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Buspirone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Buspirone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Buspirone Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Buspirone Diazepam Rectal Diastat Increased risk of CNS depression Details Buspirone Dolasetron Anzemet Increased risk of serotonin syndrome Details Buspirone Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Buspirone Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Buspirone Esketamine Nasal Spray Spravato Increased risk of sedation Details Buspirone Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Buspirone Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Buspirone Granisetron Injection Granisol Increased risk of serotonin syndrome Details Buspirone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Buspirone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Buspirone Hydroxychloroquine Plaquenil An increased risk of seizures Details Buspirone Lacosamide Injection Motpoly An increased risk of CNS depression Details Buspirone Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Buspirone Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Buspirone Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Buspirone Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Buspirone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Buspirone Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Buspirone Metoclopramide Injection Gimoti Increased risk of CNS depression Details Buspirone Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Buspirone Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Buspirone Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Buspirone Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Buspirone Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Buspirone Nalbuphine Injection Nubain® Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Buspirone Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details Buspirone Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.