Buspirone

Name: Buspirone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

40 interactions 5 explained in plain English

Also sold as: Bucapsol Buspar

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Acetaminophen And Codeine Encorafenib Lenacapavir Oral Morphine Injection Mitapivat

1 Contraindicated 36 Major 3 Moderate

All (40) Contraindicated (1) Major (36) Moderate (3)

Moderate

Buspirone Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details Buspirone Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Buspirone Ketoconazole Topical Extina® Foam Increased busPIRone exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.