Busulfan Injection

36 interactions 426 cited references
Also sold as: Busulfex Busulfex® Injection Myleran
About Busulfan Injection

Busulfan injection is used to treat a certain type of chronic myelogenous leukemia (CML; a type of cancer of the white blood cells) in combination with other medications to destroy bone marrow and cancer cells in preparation for a bone marrow transplant. Busulfan is in a class of medications called alkylating agents. I… Read the full Busulfan Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live
9 Contraindicated 22 Major 5 Moderate
All (36) Contraindicated (9) Major (22) Moderate (5)

Contraindicated

Busulfan Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Busulfan Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Busulfan Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Busulfan Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Busulfan Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Busulfan Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Busulfan Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Busulfan Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Busulfan Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Busulfan Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Busulfan Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Busulfan Injection Azathioprine Azasan An increased risk of hepatotoxicity Details Busulfan Injection Blinatumomab Increased busulfan exposure Details Busulfan Injection Bupropion Aplenzin Increased risk of seizures Details Busulfan Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Busulfan Injection Clomipramine Anafranil Increased risk of seizures Details Busulfan Injection Deferasirox Exjade Increased busulfan exposure Details Busulfan Injection Deferiprone Ferriprox Increased busulfan exposure Details Busulfan Injection Deferoxamine Mesylate Increased busulfan exposure Details Busulfan Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Busulfan Injection Hydroxychloroquine Plaquenil An increased risk of seizures Details Busulfan Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Busulfan Injection Itraconazole Sporanox Increased busulfan exposure and an increased risk of busulfan-related adverse effects Details Busulfan Injection Ketoconazole Extina Increased busulfan exposure Details Busulfan Injection Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Busulfan Injection Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Busulfan Injection Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Busulfan Injection Metronidazole Flagyl Increased busulfan exposure and an increased risk of busulfan toxicity Details Busulfan Injection Rifampin Rifadin Reduced busulfan exposure Details Busulfan Injection Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Busulfan Injection Tramadol ConZip An increased risk of seizure Details

Moderate

Busulfan Injection Acetaminophen Acephen Reduced busulfan clearance Details Busulfan Injection Fosphenytoin Cerebyx Decreased plasma concentrations of busulfan Details Busulfan Injection Ketobemidone An increase in busulfan and ketobemidone plasma levels Details Busulfan Injection Phenytoin Dilantin Decreased plasma concentrations of busulfan Details Busulfan Injection Thioguanine Tabloid An increased risk of nodular regenerative hyperplasia of the liver Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.