Busulfan Injection

Name: Busulfan Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

36 interactions 426 cited references

Also sold as: Busulfex Busulfex® Injection Myleran

About Busulfan Injection

Busulfan injection is used to treat a certain type of chronic myelogenous leukemia (CML; a type of cancer of the white blood cells) in combination with other medications to destroy bone marrow and cancer cells in preparation for a bone marrow transplant. Busulfan is in a class of medications called alkylating agents. I… Read the full Busulfan Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live

9 Contraindicated 22 Major 5 Moderate

All (36) Contraindicated (9) Major (22) Moderate (5)

Moderate

Busulfan Injection Acetaminophen Acephen Reduced busulfan clearance Details Busulfan Injection Fosphenytoin Cerebyx Decreased plasma concentrations of busulfan Details Busulfan Injection Ketobemidone An increase in busulfan and ketobemidone plasma levels Details Busulfan Injection Phenytoin Dilantin Decreased plasma concentrations of busulfan Details Busulfan Injection Thioguanine Tabloid An increased risk of nodular regenerative hyperplasia of the liver Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.