Butalbital

Name: Butalbital Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

30 interactions 3 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Linezolid Injection Diphenhydramine Injection Levonorgestrel Intrauterine System Levonorgestrel Nalbuphine Injection

26 Major 4 Moderate

All (30) Major (26) Moderate (4)

Moderate

Butalbital Capsaicin Arthricare for Women Moisturizing Increased or decreased effectiveness of barbiturates Details Butalbital Capsaicin Topical Aspercreme Warming® Increased or decreased effectiveness of barbiturates Details Butalbital Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased or decreased effectiveness of barbiturates Details Butalbital Ospemifene Osphena Decreased ospemifene exposure and efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.