Butalbital

30 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Linezolid Injection Diphenhydramine Injection Levonorgestrel Intrauterine System Levonorgestrel Nalbuphine Injection
26 Major 4 Moderate
All (30) Major (26) Moderate (4)

Major

Butalbital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression Details Butalbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Butalbital Buprenorphine Belbuca Explained An increased risk of CNS depression Details Butalbital Aripiprazole Injection Abilify An increased risk of CNS depression Details Butalbital Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Butalbital Butorphanol Injection Butorphic An increased risk of CNS depression Details Butalbital Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression Details Butalbital Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Butalbital Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Butalbital Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Butalbital Diazepam Rectal Diastat An increased risk of CNS depression Details Butalbital Diphenhydramine Injection Banophen An increased risk of CNS depression Details Butalbital Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Butalbital Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Butalbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Butalbital Esketamine Nasal Spray Spravato Increased risk of sedation Details Butalbital Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression Details Butalbital Hydromorphone Injection Dilaudid An increased risk of CNS depression Details Butalbital Hydromorphone Rectal available generically An increased risk of CNS depression Details Butalbital Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Butalbital Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Butalbital Linezolid Injection Zyvox An increased risk of CNS depression Details Butalbital Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Butalbital Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Butalbital Morphine Injection Astramorph® PF An increased risk of CNS depression Details Butalbital Nalbuphine Injection Nubain® An increased risk of CNS depression Details

Moderate

Butalbital Capsaicin Arthricare for Women Moisturizing Increased or decreased effectiveness of barbiturates Details Butalbital Capsaicin Topical Aspercreme Warming® Increased or decreased effectiveness of barbiturates Details Butalbital Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased or decreased effectiveness of barbiturates Details Butalbital Ospemifene Osphena Decreased ospemifene exposure and efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.