Butorphanol Injection

258 interactions 299 cited references
Also sold as: Butorphic Dolorex Solution Stadol® Torbugesic Torphadine Vetorphic
About Butorphanol Injection

Butorphanol injection is used to relieve moderate to severe pain. Butorphanol injection is also used to relieve pain during labor and to prevent pain and decrease awareness before or during surgery. Butorphanol is in a class of medications called opioid agonist-antagonists. It works by changing the way the body senses… Read the full Butorphanol Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Safinamide Samidorphan Tranylcypromine Phenelzine Naltrexone Isocarboxazid
6 Contraindicated 245 Major 7 Moderate
All (258) Contraindicated (6) Major (245) Moderate (7)

Contraindicated

Butorphanol Injection Isocarboxazid Marplan An increased risk of CNS depression Details Butorphanol Injection Naltrexone ReVia Precipitation of opioid withdrawal symptoms; decreased opioid effectiveness Details Butorphanol Injection Phenelzine Nardil An increased risk of serotonin syndrome Details Butorphanol Injection Safinamide Xadago Increased risk of serotonin syndrome Details Butorphanol Injection Samidorphan Decreased opioid efficacy and precipitation of opioid withdrawal Details Butorphanol Injection Tranylcypromine Parnate An increased risk of serotonin syndrome and an increased risk of CNS depression Details

Major

Butorphanol Injection Acepromazine PROMACE Increased risk of respiratory and CNS depression Details Butorphanol Injection Alfentanil An increased risk of CNS depression, profound sedation, respiratory depression, hypotension, coma and death, reduced analgesic eff... Details Butorphanol Injection Almotriptan Increased risk of serotonin syndrome Details Butorphanol Injection Alprazolam Xanax Increased risk of respiratory and CNS depression Details Butorphanol Injection Amifampridine Increased risk of seizures Details Butorphanol Injection Amineptine Increased risk of serotonin syndrome Details Butorphanol Injection Amitriptyline Elavil Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Injection Amitriptylinoxide Increased risk of serotonin syndrome Details Butorphanol Injection Amobarbital Amytal Increased risk of respiratory and CNS depression Details Butorphanol Injection Amoxapine Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Injection Amphetamine Dexedrine An increased risk of serotonin syndrome Details Butorphanol Injection Aripiprazole Abilify Increased risk of respiratory and CNS depression Details Butorphanol Injection Asenapine Saphris Increased risk of respiratory and CNS depression Details Butorphanol Injection Baclofen Fleqsuvy Increased risk of respiratory and CNS depression Details Butorphanol Injection Benperidol Increased risk of respiratory and CNS depression Details Butorphanol Injection Benzhydrocodone Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Injection Benzphetamine An increased risk of serotonin syndrome Details Butorphanol Injection Bromazepam Increased risk of respiratory and CNS depression Details Butorphanol Injection Bromopride Potentiation of sedative effects Details Butorphanol Injection Brompheniramine Respa-BR Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Injection Buprenorphine Belbuca Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Butorphanol Injection Bupropion Aplenzin Increased risk of seizures Details Butorphanol Injection Buspirone Bucapsol Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Butorphanol Injection Butabarbital Increased risk of respiratory and CNS depression Details Butorphanol Injection Butalbital An increased risk of CNS depression Details Butorphanol Injection Calcium Oxybate Xywav An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Butorphanol Injection Cannabidiol Epidiolex Increased risk of CNS depression and an increased risk of sedation and somnolence Details Butorphanol Injection Cannabis An increased risk of CNS depression Details Butorphanol Injection Carbamazepine Carbatrol Increased risk of serotonin syndrome and an increased risk of respiratory depression, profound sedation, hypotension and syncope Details Butorphanol Injection Carbidopa Lodosyn An increased risk of CNS depression Details Butorphanol Injection Carbinoxamine Carbzah An increased risk of CNS depression Details Butorphanol Injection Carisoprodol Soma Increased risk of respiratory and CNS depression Details Butorphanol Injection Carphenazine Increased risk of respiratory and CNS depression Details Butorphanol Injection Cetirizine Aller-Tec Increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.