Calcifediol

63 interactions 23 cited references
Also sold as: Rayaldee Rayaldee®
About Calcifediol

Calcifediol is used to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone [PTH; a natural substance needed to control the amount of calcium in the blood], ) in certain adults with chronic kidney disease (condition in which the kidneys stop working slowly and gradual… Read the full Calcifediol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Burosumab-Twza Injection Burosumab-Twza Diazepam Nasal Spray Brivaracetam Injection Boceprevir Midazolam Injection
2 Contraindicated 59 Major 2 Moderate
All (63) Contraindicated (2) Major (59) Moderate (2)

Contraindicated

Calcifediol Burosumab-Twza Injection Crysvita Increased risk of hyperphosphatemia Details Calcifediol Burosumab-Twza Increased risk of hyperphosphatemia Details

Major

Calcifediol Brivaracetam Briviact Altered serum levels of calcifediol Details Calcifediol Brivaracetam Injection Briviact Altered serum levels of calcifediol Details Calcifediol Boceprevir Altered serum levels of calcifediol Details Calcifediol Carbamazepine Carbatrol Altered serum levels of calcifediol Details Calcifediol Clarithromycin Biaxin Altered serum levels of calcifediol Details Calcifediol Clobazam Onfi Altered serum levels of calcifediol Details Calcifediol Clonazepam Klonopin Altered serum levels of calcifediol Details Calcifediol Clorazepate Tranxene Altered serum levels of calcifediol Details Calcifediol Cobicistat Tybost Altered serum levels of calcifediol Details Calcifediol Conivaptan Vaprisol Altered serum levels of calcifediol Details Calcifediol Diazepam Diastat Altered serum levels of calcifediol Details Calcifediol Eslicarbazepine Acetate Aptiom Altered serum levels of calcifediol Details Calcifediol Ethosuximide Zarontin Altered serum levels of calcifediol Details Calcifediol Ethotoin Altered serum levels of calcifediol Details Calcifediol Ezogabine Gabitril Altered serum levels of calcifediol Details Calcifediol Felbamate Felbatol Altered serum levels of calcifediol Details Calcifediol Fosphenytoin Cerebyx Altered serum levels of calcifediol Details Calcifediol Gabapentin Gabarone Altered serum levels of calcifediol Details Calcifediol Gabapentin Enacarbil Horizant Altered serum levels of calcifediol Details Calcifediol Idelalisib Zydelig Altered serum levels of calcifediol Details Calcifediol Indinavir Altered serum levels of calcifediol Details Calcifediol Itraconazole Sporanox Altered serum levels of calcifediol Details Calcifediol Ketoconazole Extina Altered serum levels of calcifediol Details Calcifediol Lacosamide Motpoly Altered serum levels of calcifediol Details Calcifediol Lamotrigine Lamictal Altered serum levels of calcifediol Details Calcifediol Levetiracetam Elepsia Altered serum levels of calcifediol Details Calcifediol Lopinavir Altered serum levels of calcifediol Details Calcifediol Lorazepam Ativan Altered serum levels of calcifediol Details Calcifediol Methsuximide Celontin Altered serum levels of calcifediol Details Calcifediol Midazolam Altered serum levels of calcifediol Details Calcifediol Nefazodone Altered serum levels of calcifediol Details Calcifediol Nelfinavir Viracept Altered serum levels of calcifediol Details Calcifediol Oxcarbazepine Oxtellar Altered serum levels of calcifediol Details Calcifediol Perampanel FYCOMPA Altered serum levels of calcifediol Details Calcifediol Phenobarbital Fidoquel Altered serum levels of calcifediol Details Calcifediol Phenytoin Dilantin Altered serum levels of calcifediol Details Calcifediol Posaconazole Noxafil Altered serum levels of calcifediol Details Calcifediol Pregabalin Bonqat Altered serum levels of calcifediol Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.