Calcium Oxybate

25 interactions 2 explained in plain English

Also sold as: Xywav

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diphenhydramine Injection Diphenhydramine Topical Acetaminophen And Codeine Morphine Injection Butorphanol Injection Butorphanol Nasal Spray

2 Contraindicated 22 Major 1 Moderate

All (25) Contraindicated (2) Major (22) Moderate (1)

Major

Calcium Oxybate Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Buprenorphine Belbuca Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Aripiprazole Injection Abilify An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Asenapine Transdermal Patch Secuado An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Butorphanol Injection Butorphic An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Cetirizine Injection Aller-Tec An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Cetirizine Ophthalmic Zerviate An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Diazepam Nasal Spray Valtoco An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Diazepam Rectal Diastat An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Esketamine Nasal Spray Spravato An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Hydromorphone Injection Dilaudid An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Hydromorphone Rectal available generically An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Lacosamide Injection Motpoly An increased risk of CNS depression Details Calcium Oxybate Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Calcium Oxybate Metoclopramide Injection Gimoti An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Metoclopramide Nasal Spray Gimoti An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Midazolam Nasal Spray Nayzilam An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Midazolam Injection Nayzilam An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Morphine Injection Astramorph® PF An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Calcium Oxybate Nalbuphine Injection Nubain® An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details

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