Cannabis

41 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Diphenhydramine Injection Morphine Injection Methylergonovine Butorphanol Injection Butorphanol Nasal Spray

26 Major 15 Moderate

All (41) Major (26) Moderate (15)

Major

Cannabis Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression Details Cannabis Buprenorphine Belbuca Explained Increased buprenorphine and norbuprenorphine (active metabolite) plasma levels Details Cannabis Aripiprazole Injection Abilify An increased risk of CNS depression Details Cannabis Asenapine Transdermal Patch Secuado An increased risk of CNS depression Details Cannabis Butorphanol Injection Butorphic An increased risk of CNS depression Details Cannabis Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression Details Cannabis Cetirizine Injection Aller-Tec An increased risk of CNS depression Details Cannabis Cetirizine Ophthalmic Zerviate An increased risk of CNS depression Details Cannabis Diazepam Nasal Spray Valtoco An increased risk of CNS depression Details Cannabis Diazepam Rectal Diastat An increased risk of CNS depression Details Cannabis Diphenhydramine Injection Banophen An increased risk of CNS depression Details Cannabis Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression Details Cannabis Esketamine Nasal Spray Spravato An increased risk of CNS depression Details Cannabis Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression Details Cannabis Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Cannabis Hydromorphone Injection Dilaudid An increased risk of CNS depression Details Cannabis Hydromorphone Rectal available generically An increased risk of CNS depression Details Cannabis Lacosamide Injection Motpoly An increased risk of CNS depression Details Cannabis Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Cannabis Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Cannabis Methylergonovine Methergine Increased methylergonovine exposure Details Cannabis Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Cannabis Midazolam Injection Nayzilam An increased risk of CNS depression Details Cannabis Morphine Injection Astramorph® PF An increased risk of CNS depression Details Cannabis Nalbuphine Injection Nubain® An increased risk of CNS depression Details Cannabis Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Cannabis Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Cannabis Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Cannabis Cyclosporine Injection Atopica Increased cannabis exposure Details Cannabis Cyclosporine Ophthalmic Cequa Increased cannabis exposure Details Cannabis Dexamethasone Injection Decadron Reduced cannabis exposure Details Cannabis Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced cannabis exposure Details Cannabis Dofetilide Tikosyn Increased dofetilide exposure Details Cannabis Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Cannabis Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Cannabis Istradefylline Nourianz Reduced CYP1A2 substrate exposure Details Cannabis Ketoconazole Topical Extina® Foam Increased cannabis exposure Details Cannabis Letermovir Injection Prevymis Increased cannabis exposure Details Cannabis Mexiletine Mexitil® Reduced CYP1A2 substrate exposure Details Cannabis Nafcillin Injection Unipen® Injection Reduced cannabis exposure Details

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