Canrenoate

20 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Moexipril Morphine Injection Arsenic Trioxide Perindopril Benazepril
18 Major 1 Moderate 1 Minor
All (20) Major (18) Moderate (1) Minor (1)

Major

Canrenoate Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Canrenoate Lisinopril Prinivil Explained Increased risk of hyperkalemia Details Canrenoate Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Canrenoate Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Canrenoate Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Canrenoate Benazepril Lotensin Increased risk of hyperkalemia Details Canrenoate Captopril Capoten® Increased risk of hyperkalemia Details Canrenoate Cyclosporine Injection Atopica An increased risk of hyperkalemia Details Canrenoate Cyclosporine Ophthalmic Cequa An increased risk of hyperkalemia Details Canrenoate Enalapril Epaned Increased risk of hyperkalemia Details Canrenoate Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Canrenoate Fosinopril Monopril® Increased risk of hyperkalemia Details Canrenoate Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Canrenoate Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Canrenoate Lithium Carbonate Lithobid Increased lithium concentrations and an increased risk of lithium toxicity (weakness, tremor, excessive thirst, confusion) Details Canrenoate Moexipril Univasc® Increased risk of hyperkalemia Details Canrenoate Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Canrenoate Perindopril Aceon Increased risk of hyperkalemia Details

Moderate

Canrenoate Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details

Minor

Canrenoate Fludrocortisone Acetate Florinef® A paradoxical dose-related increase in urinary potassium excretion Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.