Canrenoate and Acetaminophen And Codeine: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jun 30, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Acetaminophen And Codeine
Canrenoate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
You're taking a pain medicine that contains codeine along with a water pill (diuretic) called canrenoate. Codeine can nudge your body to release a hormone that makes you hold onto more water. That may make your water pill work a little less well, so you might notice less urination or a change in your blood pressure.
The good news is this is based mostly on theory, not strong real-world proof. Your care team can easily keep an eye on this and adjust your water pill dose if needed. Please don't stop or change either medicine on your own. Just let your pharmacist or doctor know you take both.
Effect: Codeine may reduce the diuretic efficacy of canrenoate.
Mechanism: Opioid-mediated stimulation of antidiuretic hormone (ADH) release promotes water retention, opposing the diuretic/natriuretic action of the aldosterone antagonist canrenoate. This is a PD interaction; codeine is a CYP2D6 prodrug for analgesia, but the diuretic effect here is unrelated to that activation.
Evidence: Theoretical. Onset: unspecified. Severity on file: major.
- Monitor urine output, weight/edema, and blood pressure.
- Diuretic dose may need to be individualized and titrated upward if diminished diuresis is observed.
What happens
Reduced diuretic efficacy
Interaction Deep Dive
Concomitant use of codeine with diuretics may reduce the efficacy of diuretics by inducing the release of anti-diuretic hormone. Monitor patients for signs of diminished diuresis and/or effects on blood pressure and increase the dosage of the diuretic as needed1.
Why it happens (mechanism)
Increased opioid-mediated release of antidiuretic hormone
How to manage this interaction
Keep taking both medications as prescribed. This concern is theoretical, and your care team can manage it easily.
- Your team may monitor you more closely for signs the water pill is working less well, such as less urination, swelling, weight gain, or blood pressure changes.
- If needed, your diuretic dose may be adjusted and individualized by your care team.
- Tell your pharmacist or prescriber that you take both, and report any new swelling, sudden weight gain, or unusual blood pressure readings.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Canrenoate and Acetaminophen And Codeine together?
Codeine may slightly weaken your canrenoate water pill by causing water retention, but this is theoretical and easily managed. Keep taking both as prescribed and let your care team monitor and adjust your diuretic if needed. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Canrenoate and Acetaminophen And Codeine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Canrenoate and Acetaminophen And Codeine interaction managed?
Keep taking both medications as prescribed. This concern is theoretical, and your care team can manage it easily. Your team may monitor you more closely for signs the water pill is working less well, such as less urination, swelling, weight gain, or blood pressure changes. If needed, your diuretic dose may be adjusted and individualized by your care team. Tell your pharmacist or prescriber that yo… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Canrenoate or Acetaminophen And Codeine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: CARISOPRODOL, ASPIRIN, CODEINE PHOSPHATE oral tablets, carisoprodol, aspirin, codeine phosphate oral tablets. Ingenus Pharmaceuticals LLC (per DailyMed), Orlando, FL, 2021. DailyMed
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