Capivasertib and Ketoconazole Topical: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Capivasertib
Ketoconazole Topical
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased capivasertib exposure and an increased risk of capivasertib-related adverse reactions
Interaction Deep Dive
Avoid concomitant use of capivasertib (a CYP3A substrate) with strong CYP3A inhibitors. If concomitant use cannot be avoided, reduce the dosage of capivasertib to 320 mg orally twice daily for 4 days followed by 3 days off and monitor patients for adverse reactions. After discontinuation of a strong CYP3A inhibitor, resume the capivasertib dosage (after 3 to 5 half-lives of the inhibitor) that was taken prior to initiating the strong CYP3A inhibitor. Strong CYP3A inhibitors increase capivasertib exposure which may increase the risk of capivasertib adverse reactions. Capivasertib Cmax is predicted to increase by 1.4-fold and AUC by 1.7-fold following concomitant use with itraconazole (a strong CYP3A inhibitor)1.
Why it happens (mechanism)
Inhibition of CYP3A-mediated metabolism of capivasertib
Literature reports
1 report — tap to read
a) Capivasertib Cmax is predicted to increase by 1.4-fold and AUC by 1.7-fold following concomitant use with itraconazole (a strong CYP3A inhibitor) 1.
Common questions
Can I take Capivasertib and Ketoconazole Topical together?
Increased capivasertib exposure and an increased risk of capivasertib-related adverse reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Capivasertib and Ketoconazole Topical interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Capivasertib or Ketoconazole Topical need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: TRUQAP(TM) oral tablets, capivasertib oral tablets. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2023. DailyMed
Keep reading about Capivasertib
Keep reading about Ketoconazole Topical
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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