Capivasertib and Colchicine: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Capivasertib
Colchicine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Taking these two together can let colchicine build up in your body. Capivasertib (Truqap) can slow down a liver enzyme that normally breaks colchicine down. When that clean-up slows, more colchicine stays in your blood, which raises the chance of side effects like stomach upset, diarrhea, muscle pain or weakness, and in serious cases, more dangerous problems.
The good news is this is very manageable. Don't stop or change either medicine on your own. Let your pharmacist or doctor know you take both. They can lower your colchicine dose or space it out and watch you more closely so you stay safe.
Effect: Increased colchicine exposure and risk of colchicine toxicity.
Mechanism: Capivasertib inhibits CYP3A4-mediated metabolism of colchicine, reducing clearance and increasing systemic exposure. Colchicine is also a P-gp substrate with a narrow therapeutic margin, so even modest exposure increases can be clinically relevant.
- Direction: Increased colchicine effect/toxicity
- Onset: Unspecified
- Evidence: Theoretical
- Management: Avoid concomitant use where possible. If necessary, reduce colchicine daily dose or dosing frequency and monitor for toxicity (GI symptoms, myopathy, neuropathy, cytopenias). Consider greater caution in renal or hepatic impairment.
What happens
Increased colchicine exposure and an increased risk of colchicine-related toxicity
Interaction Deep Dive
Because of the risk of serious, potentially fatal toxicity, colchicine should not be taken together with CYP3A4 inhibitors. When these two agents must be used at the same time, the colchicine regimen should be modified, either by lowering the daily amount or by administering it less frequently, while closely watching for signs of colchicine toxicity1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of colchicine
How to manage this interaction
This can be managed by your care team. Keep taking both medicines as prescribed unless your prescriber tells you otherwise.
- Tell your pharmacist and doctor that you take both capivasertib and colchicine.
- Your team may lower your colchicine dose or space out how often you take it, and monitor you more closely for signs of toxicity.
- Watch for and report diarrhea, nausea/vomiting, muscle pain or weakness, numbness or tingling, or unusual fatigue.
- In some cases your team may prefer avoiding the combination and choosing an alternative.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Capivasertib and Colchicine together?
Capivasertib can raise colchicine levels and the risk of serious side effects, so tell your care team you take both; they may lower or space out your colchicine dose and watch you closely. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Capivasertib and Colchicine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Capivasertib and Colchicine interaction managed?
This can be managed by your care team. Keep taking both medicines as prescribed unless your prescriber tells you otherwise. Tell your pharmacist and doctor that you take both capivasertib and colchicine. Your team may lower your colchicine dose or space out how often you take it, and monitor you more closely for signs of toxicity. Watch for and report diarrhea, nausea/vomiting, muscle pain or weak… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Capivasertib or Colchicine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: MITIGARE(R) oral capsules, colchicine oral capsules. Hikma Specialty USA Inc (per FDA), Columbus, OH, 2024. DailyMed
Keep reading about Capivasertib
Keep reading about Colchicine
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