Capivasertib and Nafcillin Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Capivasertib
Nafcillin Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced capivasertib exposure and reduced efficacy of capivasertib
Interaction Deep Dive
Avoid concomitant use of capivasertib with a moderate CYP3A4 inducer. Concomitant use of capivasertib with a moderate CYP3A4 inducer may decrease capivasertib exposure, which may reduce the effectiveness of capivasertib. Capivasertib Cmax is predicted to decrease by 50% and AUC by 60% following concomitant use with efavirenz (a moderate CYP3A inducer)1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of capivasertib
Literature reports
1 report — tap to read
a) Capivasertib Cmax is predicted to decrease by 50% and AUC by 60% following concomitant use with efavirenz (a moderate CYP3A inducer) 1.
Common questions
Can I take Capivasertib and Nafcillin Injection together?
Reduced capivasertib exposure and reduced efficacy of capivasertib Always confirm with your pharmacist or prescriber before making any change.
How serious is the Capivasertib and Nafcillin Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Capivasertib or Nafcillin Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: TRUQAP(TM) oral tablets, capivasertib oral tablets. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2023. DailyMed
Keep reading about Capivasertib
Keep reading about Nafcillin Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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