Cefazolin Injection

Name: Cefazolin Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

5 interactions 288 cited references

Also sold as: Ancef® Kefzol®

About Cefazolin Injection

Cefazolin injection is used to treat certain infections caused by bacteria including skin, bone, joint, genital, blood, heart valve, respiratory tract (including pneumonia), biliary tract, and urinary tract infections. Cefazolin injection also may be used before, during, and sometimes for a brief period after surgery i… Read the full Cefazolin Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cholera Vaccine, Live Furosemide Rifampin

3 Major 2 Moderate

All (5) Major (3) Moderate (2)

Major

Cefazolin Injection Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Cefazolin Injection Furosemide Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefazolin Injection Rifampin Rifadin Increased or prolonged prothrombin time and an increased risk of bleeding Details

Moderate

Cefazolin Injection Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details Cefazolin Injection Warfarin Coumadin An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.