Cefpodoxime

26 interactions 115 cited references
Also sold as: Banan® Cefpoderm Dermaceph Simplicef Vantin®
About Cefpodoxime

Cefpodoxime is a cephalosporin antibiotic used to treat bacterial infections of the respiratory tract, skin, ears, sinuses, throat, and urinary tract. Read the full Cefpodoxime drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Estradiol Estradiol Topical Estradiol Transdermal Patch Furosemide Injection Levonorgestrel Levonorgestrel Intrauterine System
6 Major 20 Moderate
All (26) Major (6) Moderate (20)

Major

Cefpodoxime Estradiol Delestrogen Decreased contraceptive effectiveness Details Cefpodoxime Estradiol Topical Divigel Decreased contraceptive effectiveness Details Cefpodoxime Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Cefpodoxime Furosemide Injection Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefpodoxime Levonorgestrel After banger Decreased contraceptive effectiveness Details Cefpodoxime Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details

Moderate

Cefpodoxime Aluminum Carbonate, Basic Decreased cefpodoxime effectiveness Details Cefpodoxime Aluminum Hydroxide AlternaGEL® Decreased cefpodoxime effectiveness Details Cefpodoxime Aluminum Phosphate Decreased cefpodoxime effectiveness Details Cefpodoxime Calcium Decreased cefpodoxime effectiveness Details Cefpodoxime Calcium Carbonate Alka-Mints Decreased cefpodoxime effectiveness Details Cefpodoxime Cimetidine Tagamet Decreased cefpodoxime effectiveness Details Cefpodoxime Dihydroxyaluminum Aminoacetate Decreased cefpodoxime effectiveness Details Cefpodoxime Dihydroxyaluminum Sodium Carbonate Decreased cefpodoxime effectiveness Details Cefpodoxime Famotidine Calmicid Decreased cefpodoxime effectiveness Details Cefpodoxime Magaldrate Decreased cefpodoxime effectiveness Details Cefpodoxime Magnesium Carbonate Decreased cefpodoxime effectiveness Details Cefpodoxime Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Decreased cefpodoxime effectiveness Details Cefpodoxime Magnesium Oxide Mag-Ox 400 Decreased cefpodoxime effectiveness Details Cefpodoxime Magnesium Trisilicate Decreased cefpodoxime effectiveness Details Cefpodoxime Nizatidine Axid® Decreased cefpodoxime effectiveness Details Cefpodoxime Probenecid Increased serum cefpodoxime levels Details Cefpodoxime Ranitidine Decreased cefpodoxime effectiveness Details Cefpodoxime Sodium Bicarbonate Alka-Seltzer® Heartburn Decreased cefpodoxime effectiveness Details Cefpodoxime Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details Cefpodoxime Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.