Chloroprocaine

25 interactions 104 cited references

Read the full Chloroprocaine drug information page

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Articaine Bupivacaine Bupivacaine Hydrochloride Bupivacaine Liposome Hyaluronidase
1 Contraindicated 7 Major 17 Moderate
All (25) Contraindicated (1) Major (7) Moderate (17)

Contraindicated

Chloroprocaine Isocarboxazid Marplan An increased risk of hypotension Details

Major

Chloroprocaine Articaine An increased risk of methemoglobinemia Details Chloroprocaine Bupivacaine Exparel Increased risk of toxicity Details Chloroprocaine Bupivacaine Hydrochloride Increased risk of toxicity Details Chloroprocaine Bupivacaine Liposome Exparel Increased anesthetic toxicity Details Chloroprocaine Hyaluronidase An increased incidence of a systemic reaction to the anesthetic Details Chloroprocaine Lidocaine Akten An increased risk of local anesthetic toxicity and an increased risk methemoglobinemia Details Chloroprocaine St John's Wort An increased risk of cardiovascular collapse and/or delayed emergence from anesthesia Details

Moderate

Chloroprocaine Cisatracurium Enhanced neuromuscular blocking action Details Chloroprocaine Morphine Antagonism of the analgesic effect of epidural morphine by epidural chloroprocaine Details Chloroprocaine Morphine Sulfate Liposome Antagonism of the analgesic effect of epidural morphine by epidural chloroprocaine Details Chloroprocaine Rapacuronium Enhanced neuromuscular blockade Details Chloroprocaine Sulfacytine Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfadiazine Microsulfon® Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfadoxine Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfaguanidine Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfamerazine Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfamethazine Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfamethizole Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfamethoxazole Sustain Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfaphenazole Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfapyridine Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfasalazine Azulfidine Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Sulfisoxazole Antagonism of the sulfonamide's antibacterial effect Details Chloroprocaine Morphine Injection Astramorph® PF Antagonism of the analgesic effect of epidural morphine by epidural chloroprocaine Details

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