Chlorpropamide

59 interactions 3 explained in plain English

Also sold as: Diabinese® Glucamide®

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acarbose Abiraterone Ofloxacin Insulin Detemir (Rdna Origin) Injection Levofloxacin Injection Orlistat

29 Major 30 Moderate

All (59) Major (29) Moderate (30)

Major

Chlorpropamide Acarbose Prandase® Explained An increased risk of hypoglycemia Details Chlorpropamide Abiraterone Abirtega An increased risk of severe hypoglycemia Details Chlorpropamide Chloroquine Aralen® Hypoglycemia Details Chlorpropamide Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Disopyramide Norpace Increased risk of hypoglycemia Details Chlorpropamide Dulaglutide Injection Trulicity Increased risk of hypoglycemia Details Chlorpropamide Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Chlorpropamide Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Chlorpropamide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Chlorpropamide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Chlorpropamide Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Chlorpropamide Lanreotide Injection Somatuline An increased risk of hypoglycemia and impaired glucose regulation Details Chlorpropamide Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Levofloxacin Injection Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Lixisenatide Injection Adlyxin® Increased risk of hypoglycemia Details Chlorpropamide Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Chlorpropamide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Chlorpropamide Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Moxifloxacin Injection Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Moxifloxacin Ophthalmic Moxeza® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Chlorpropamide Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Chlorpropamide Ofloxacin Floxin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Chlorpropamide Orlistat Alli An increased risk of hypoglycemia Details

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