Chlorpropamide

59 interactions 3 explained in plain English

Also sold as: Diabinese® Glucamide®

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acarbose Abiraterone Ofloxacin Insulin Detemir (Rdna Origin) Injection Levofloxacin Injection Orlistat

29 Major 30 Moderate

All (59) Major (29) Moderate (30)

Moderate

Chlorpropamide Lisinopril Prinivil Explained An increased risk of hypoglycemia Details Chlorpropamide Aspirin Acuprin® Increased risk of hypoglycemia Details Chlorpropamide Aspirin Rectal Aspirin Increased risk of hypoglycemia Details Chlorpropamide Atenolol Tenormin Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Benazepril Lotensin An increased risk of hypoglycemia Details Chlorpropamide Alogliptin Nesina An increased risk of hypoglycemia Details Chlorpropamide Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Captopril Capoten® An increased risk of hypoglycemia Details Chlorpropamide Chloramphenicol Injection Chloromycetin® Injection Hypoglycemia (CNS depression, seizures) Details Chlorpropamide Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Chlorpropamide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Chlorpropamide Enalapril Epaned An increased risk of hypoglycemia Details Chlorpropamide Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Exenatide Injection Bydureon Increased risk of hypoglycemia Details Chlorpropamide Fosinopril Monopril® An increased risk of hypoglycemia Details Chlorpropamide Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Levothyroxine Ermeza Worsening of glycemic control Details Chlorpropamide Linagliptin Tradjenta An increased risk of hypoglycemia Details Chlorpropamide Linezolid Injection Zyvox An increased risk of hypoglycemia Details Chlorpropamide Liraglutide Injection Saxenda An increased risk of hypoglycemia Details Chlorpropamide Metformin Fortamet® An increased risk of hypoglycemia Details Chlorpropamide Moexipril Univasc® An increased risk of hypoglycemia Details Chlorpropamide Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Chlorpropamide Perindopril Aceon An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.