Chlorzoxazone

Name: Chlorzoxazone Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

35 interactions 3 explained in plain English

Also sold as: Lorzone

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Hydromorphone Rectal Colchicine Azathioprine Mercaptopurine Nifedipine

31 Major 4 Moderate

All (35) Major (31) Moderate (4)

Moderate

Chlorzoxazone Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Chlorzoxazone Dofetilide Tikosyn Increased dofetilide exposure Details Chlorzoxazone Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Chlorzoxazone Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.