Ciclesonide and Auranofin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Auranofin
Ciclesonide
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of auranofin-related adverse effects
Interaction Deep Dive
The safety of concomitant use of auranofin and high-dose corticosteroids has not been established1. A retrospective, observational trial reported an increased risk of adverse events, including functional nervous system disorders and stroke, with combination therapy compared with gold monotherapy 2.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) A retrospective, observational study reported that the combination of gold and glucocorticoids resulted in increased adverse effects, but no additional efficacy, compared to gold monotherapy in patients with rheumatoid arthritis. Functional nervous system disorders, such as sleep disorders and headache, were reported in 14.2% taking combination therapy compared with 2% taking gold monotherapy. Stroke was reported in 21% taking combination therapy compared with 0% taking gold monotherapy. A duration of combination therapy of greater than 3 months was associated with a higher risk of adverse events 2.
Common questions
Can I take Ciclesonide and Auranofin together?
Increased risk of auranofin-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Ciclesonide and Auranofin interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Ciclesonide or Auranofin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Product Information: RIDAURA(R) oral capsules, auranofin oral capsules. Sebela Pharmaceuticals Inc (per DailyMed), Roswell, GA, 2017. DailyMed
- Malysheva OA, Wahle M, Wagner U, et al: Low-dose prednisolone in rheumatoid arthritis: adverse effects of various disease modifying antirheumatic drugs. J Rheumatol 2008; 35(6):979-985.
Keep reading about Ciclesonide
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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