Ciprofibrate

14 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Gemfibrozil Colchicine Simvastatin Atorvastatin Cyclosporine Injection Cyclosporine Ophthalmic
1 Contraindicated 8 Major 5 Moderate
All (14) Contraindicated (1) Major (8) Moderate (5)

Contraindicated

Ciprofibrate Gemfibrozil Lopid An increased risk of rhabdomyolysis and myoglobinuria Details

Major

Ciprofibrate Colchicine Colcrys Explained An increased risk of myopathy, including rhabdomyolysis Details Ciprofibrate Simvastatin Flolipid Explained An increased risk of myopathy or rhabdomyolysis Details Ciprofibrate Atorvastatin Atorvaliq An increased risk of myopathy or rhabdomyolysis Details Ciprofibrate Cyclosporine Injection Atopica Increased risk of renal dysfunction Details Ciprofibrate Cyclosporine Ophthalmic Cequa Increased risk of renal dysfunction Details Ciprofibrate Ezetimibe Zetia Increased ezetimibe exposure and an increased risk of cholelithiasis, myopathy and rhabdomyolysis Details Ciprofibrate Fluvastatin Lescol An increased risk of myopathy or rhabdomyolysis Details Ciprofibrate Lovastatin Altocor® An increased risk of myopathy or rhabdomyolysis Details

Moderate

Ciprofibrate Bempedoic Acid Nexletol An increased triglycerides and reduced high-density lipoprotein cholesterol (HDL-C) Details Ciprofibrate Glimepiride Amaryl Increased glimepiride exposure and increased blood glucose lowering effect and risk of hypoglycemia Details Ciprofibrate Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Ciprofibrate Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Ciprofibrate Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.