Clobazam

48 interactions 4 explained in plain English
Also sold as: Onfi Sympazan
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Clobazam Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine exposure, reduced active metabolite (morphine) exposure and an increased risk of CNS depression Details Clobazam Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Clobazam Aripiprazole Injection Abilify Increased risk of sedation Details Clobazam Asenapine Transdermal Patch Secuado Increased risk of sedation Details Clobazam Atogepant Qulipta Reduced atogepant exposure Details Clobazam Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Clobazam Amlodipine Amvaz® Reduced amLODIPine exposure Details Clobazam Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Clobazam Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Clobazam Calcifediol Rayaldee Altered serum levels of calcifediol Details Clobazam Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Clobazam Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Clobazam Diazepam Nasal Spray Valtoco Increased risk of sedation Details Clobazam Diazepam Rectal Diastat Increased risk of sedation Details Clobazam Diphenhydramine Injection Banophen Increased risk of sedation Details Clobazam Diphenhydramine Topical Afterbite with Antihistamine Increased risk of sedation Details Clobazam Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Clobazam Esketamine Nasal Spray Spravato Increased risk of sedation Details Clobazam Estradiol Delestrogen Decreased contraceptive effectiveness Details Clobazam Estradiol Topical Divigel Decreased contraceptive effectiveness Details Clobazam Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Clobazam Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Clobazam Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Clobazam Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Clobazam Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Clobazam Lacosamide Injection Motpoly An increased risk of CNS depression Details Clobazam Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Clobazam Levonorgestrel After banger Decreased contraceptive effectiveness Details Clobazam Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Clobazam Lumateperone Caplyta Reduced lumateperone exposure Details Clobazam Medroxyprogesterone Amen® Decreased contraceptive effectiveness Details Clobazam Medroxyprogesterone Injection Depo-Provera Decreased contraceptive effectiveness Details Clobazam Metoclopramide Injection Gimoti Increased risk of CNS depression Details Clobazam Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Clobazam Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Clobazam Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Clobazam Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Clobazam Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Clobazam Nifedipine Adalat® Reduced NIFEdipine exposure Details Clobazam Orlistat Alli Reduced efficacy of anticonvulsant Details

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