Clobazam

Name: Clobazam Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

48 interactions 4 explained in plain English

Also sold as: Onfi Sympazan

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Morphine Injection Levonorgestrel Intrauterine System Fentanyl Transdermal Patch Hydromorphone Rectal Diphenhydramine Injection Medroxyprogesterone Injection

40 Major 8 Moderate

All (48) Major (40) Moderate (8)

Moderate

Clobazam Amitriptyline Elavil Explained Increased exposure of amitriptyline Details Clobazam Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Clobazam Felbamate Felbatol Increased serum clobazam and metabolite concentrations Details Clobazam Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Clobazam Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Clobazam Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details Clobazam Ketoconazole Topical Extina® Foam Increased systemic exposure to clobazam Details Clobazam Mitapivat Aqvesme Reduced CYP2C19 substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.