Clopamide

48 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Meloxicam Injection Morphine Injection Hydromorphone Rectal Naproxen Meclofenamate Aspirin

34 Major 14 Moderate

All (48) Major (34) Moderate (14)

Major

Clopamide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Clopamide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Clopamide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Clopamide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Clopamide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Clopamide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Clopamide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Clopamide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Clopamide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Clopamide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Clopamide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Clopamide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Clopamide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Clopamide Lisinopril Prinivil Explained Reduction of blood pressure Details Clopamide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Clopamide Benazepril Lotensin Reduction of blood pressure Details Clopamide Captopril Capoten® Reduction of blood pressure Details Clopamide Cyclophosphamide Cytoxan® Increased risk of myelosuppression Details Clopamide Cyclophosphamide Injection Cytoxan® Injection Increased risk of myelosuppression Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.