Clopidogrel

359 interactions 1 explained in plain English 501 cited references

Also sold as: Plavix Plavix®

About Clopidogrel

Clopidogrel is an antiplatelet medication used to prevent heart attacks and strokes in people with heart disease or poor circulation. Read the full Clopidogrel drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Abrocitinib Defibrotide Darunavir Nalbuphine Injection Methotrexate Injection

3 Contraindicated 239 Major 115 Moderate 2 Minor

All (359) Contraindicated (3) Major (239) Moderate (115) Minor (2)

Major

Clopidogrel Etofenamate An increased risk of bleeding Details Clopidogrel Etoricoxib An increased risk of bleeding Details Clopidogrel Felbinac An increased risk of bleeding Details Clopidogrel Felodipine Plendil® Decreased antiplatelet effect and increased risk of thrombotic events Details Clopidogrel Fenoprofen Fenopron An increased risk of bleeding Details Clopidogrel Fentanyl Reduced efficacy of clopidogrel Details Clopidogrel Fepradinol An increased risk of bleeding Details Clopidogrel Feprazone An increased risk of bleeding Details Clopidogrel Floctafenine An increased risk of bleeding Details Clopidogrel Flufenamic Acid An increased risk of bleeding Details Clopidogrel Fluoxetine RECONCILE Reduced exposure of the active metabolite of clopidogrel, reduced platelet inhibition and an increased risk of bleeding Details Clopidogrel Flurbiprofen Ansaid An increased risk of bleeding Details Clopidogrel Fluvoxamine Reduced clopidogrel active metabolite exposure, reduced platelet inhibition and an increased risk of bleeding Details Clopidogrel Fondaparinux Arixtra Increased risk of bleeding Details Clopidogrel Heparin Increased risk of bleeding Details Clopidogrel Hydrocodone Hysingla Reduced efficacy of clopidogrel Details Clopidogrel Hydromorphone Dilaudid Reduced efficacy of clopidogrel Details Clopidogrel Ibrutinib Imbruvica Increased risk of bleeding Details Clopidogrel Ibuprofen Addaprin An increased risk of bleeding Details Clopidogrel Indomethacin Indocin An increased risk of bleeding Details Clopidogrel Inotersen Increased risk of bleeding Details Clopidogrel Isradipine DynaCirc® Decreased antiplatelet effect and increased risk of thrombotic events Details Clopidogrel Ketobemidone Reduced efficacy of clopidogrel Details Clopidogrel Ketoconazole Extina Reduction in clinical efficacy of clopidogrel Details Clopidogrel Ketoprofen Actron® An increased risk of bleeding Details Clopidogrel Ketorolac Acular An increased risk of bleeding Details Clopidogrel Lepirudin Increased risk of bleeding Details Clopidogrel Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Clopidogrel Levomilnacipran An increased risk of bleeding Details Clopidogrel Levorphanol Xyvona Reduced efficacy of clopidogrel Details Clopidogrel Lonafarnib Zokinvy Increased clopidogrel exposure, an increased risk of clopidogrel-related adverse effects, reduced clopidogrel active metabolite ex... Details Clopidogrel Loperamide Diamode An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Clopidogrel Lornoxicam An increased risk of bleeding Details Clopidogrel Loxoprofen An increased risk of bleeding Details Clopidogrel Lumiracoxib An increased risk of bleeding Details Clopidogrel Mavacamten Camzyos Increased mavacamten exposure, an increased risk of mavacamten-related adverse effects, reduced clopidogrel exposure and reduced e... Details Clopidogrel Meclofenamate Meclodium® An increased risk of bleeding Details Clopidogrel Mefenamic Acid Ponstel® An increased risk of bleeding Details Clopidogrel Meloxicam Alloxate An increased risk of bleeding Details Clopidogrel Melphalan Alkeran An increased risk of bleeding Details

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