Clopidogrel

359 interactions 1 explained in plain English 501 cited references

Also sold as: Plavix Plavix®

About Clopidogrel

Clopidogrel is an antiplatelet medication used to prevent heart attacks and strokes in people with heart disease or poor circulation. Read the full Clopidogrel drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Abrocitinib Defibrotide Darunavir Nalbuphine Injection Methotrexate Injection

3 Contraindicated 239 Major 115 Moderate 2 Minor

All (359) Contraindicated (3) Major (239) Moderate (115) Minor (2)

Major

Clopidogrel Meperidine Demerol Reduced efficacy of clopidogrel, an increased meperidine exposure and an increased risk of meperidine-related adverse effects Details Clopidogrel Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Clopidogrel Methadone Diskets Increased methadone exposure, an increased risk of opioid adverse effects and reduced efficacy of clopidogrel Details Clopidogrel Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Clopidogrel Milnacipran Savella An increased risk of bleeding Details Clopidogrel Morniflumate An increased risk of bleeding Details Clopidogrel Morphine Reduced efficacy of clopidogrel Details Clopidogrel Morphine Sulfate Liposome Reduced efficacy of clopidogrel Details Clopidogrel Nabumetone Relafen An increased risk of bleeding Details Clopidogrel Nadroparin Increased risk of bleeding Details Clopidogrel Nalbuphine Reduced efficacy of clopidogrel Details Clopidogrel Naproxen Aleve An increased risk of bleeding Details Clopidogrel Nefazodone An increased risk of bleeding Details Clopidogrel Nepafenac Ilevro An increased risk of bleeding Details Clopidogrel Nicardipine Cardene Decreased antiplatelet effect and increased risk of thrombotic events Details Clopidogrel Nicomorphine Reduced efficacy of clopidogrel Details Clopidogrel Nifedipine Adalat® Decreased antiplatelet effect and increased risk of thrombotic events Details Clopidogrel Niflumic Acid An increased risk of bleeding Details Clopidogrel Nimesulide An increased risk of bleeding Details Clopidogrel Nimesulide Beta Cyclodextrin An increased risk of bleeding Details Clopidogrel Nimodipine Nimotop Decreased antiplatelet effect and increased risk of thrombotic events Details Clopidogrel Nirmatrelvir Decreased clopidogrel efficacy Details Clopidogrel Nisoldipine Sular Decreased antiplatelet effect and increased risk of thrombotic events Details Clopidogrel Opium Reduced efficacy of clopidogrel Details Clopidogrel Opium Alkaloids Reduced efficacy of clopidogrel Details Clopidogrel Oxaprozin Coxanto An increased risk of bleeding Details Clopidogrel Oxycodone Oxaydo Reduced efficacy of clopidogrel Details Clopidogrel Oxymorphone Reduced efficacy of clopidogrel Details Clopidogrel Oxyphenbutazone An increased risk of bleeding Details Clopidogrel Paclitaxel Abraxane Increased PACLitaxel exposure Details Clopidogrel Paclitaxel Protein-Bound Increased PACLitaxel exposure Details Clopidogrel Papaveretum Reduced efficacy of clopidogrel Details Clopidogrel Parecoxib An increased risk of bleeding Details Clopidogrel Paregoric Reduced efficacy of clopidogrel Details Clopidogrel Parnaparin Increased risk of bleeding Details Clopidogrel Paroxetine Paxil An increased risk of bleeding Details Clopidogrel Phenindione Increased risk of bleeding Details Clopidogrel Phenobarbital Fidoquel Reduced CYP2C19 substrate exposure and reduced efficacy of CYP2C19 substrate Details Clopidogrel Phenprocoumon Increased risk of bleeding Details Clopidogrel Phenylbutazone Equi-Phar An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.