Clopidogrel

359 interactions 1 explained in plain English 501 cited references
Also sold as: Plavix Plavix®
About Clopidogrel

Clopidogrel is an antiplatelet medication used to prevent heart attacks and strokes in people with heart disease or poor circulation. Read the full Clopidogrel drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Clopidogrel Tovorafenib Ojemda Increased tovorafenib exposure and an increased risk of tovorafenib-related adverse effects Details Clopidogrel Tramadol ConZip Reduced efficacy of clopidogrel Details Clopidogrel Trazodone Raldesy Increased risk of bleeding Details Clopidogrel Treprostinil Orenitram An increased risk of bleeding Details Clopidogrel Tucatinib Tukysa Increased tucatinib exposure and risk of toxicity Details Clopidogrel Turmeric An increased risk of bleeding Details Clopidogrel Valdecoxib An increased risk of bleeding Details Clopidogrel Venlafaxine An increased risk of bleeding Details Clopidogrel Verapamil Calan Decreased antiplatelet effect and increased risk of thrombotic events Details Clopidogrel Vilazodone Viibryd An increased risk of bleeding Details Clopidogrel Vonoprazan Voquezna Reduced exposure of the active metabolite of clopidogrel Details Clopidogrel Vorapaxar Zontivity An increased risk of bleeding Details Clopidogrel Voriconazole Vfend Altered clopidogrel exposure, an increased risk of clopidogrel-related adverse effects, reduced platelet inhibition, an increased... Details Clopidogrel Vortioxetine Trintellix An increased risk of bleeding Details Clopidogrel Warfarin Coumadin An increased risk of bleeding Details Clopidogrel Zanubrutinib Brukinsa Increased clopidogrel active metabolite exposure, an increased risk of platelet inhibition and an increased risk of bleeding Details Clopidogrel Dabigatran Pradaxa® An increased risk of bleeding Details Clopidogrel Dalteparin Injection Fragmin Increased risk of bleeding Details Clopidogrel Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Clopidogrel Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Clopidogrel Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Clopidogrel Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Clopidogrel Enoxaparin Injection Lovenox Increased risk of bleeding Details Clopidogrel Esomeprazole Injection Nexium Reduced clopidogrel active metabolite exposure and reduced antiplatelet activity Details Clopidogrel Fentanyl Transdermal Patch Duragesic® Reduced efficacy of clopidogrel Details Clopidogrel Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Clopidogrel Fondaparinux Injection Arixtra Increased risk of bleeding Details Clopidogrel Heparin Injection Lipo-Hepin® Increased risk of bleeding Details Clopidogrel Hydromorphone Injection Dilaudid Reduced efficacy of clopidogrel Details Clopidogrel Hydromorphone Rectal available generically Reduced efficacy of clopidogrel Details Clopidogrel Ketoconazole Topical Extina® Foam Reduction in clinical efficacy of clopidogrel Details Clopidogrel Ketorolac Injection Acular An increased risk of bleeding Details Clopidogrel Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Clopidogrel Ketorolac Ophthalmic Acular An increased risk of bleeding Details Clopidogrel Meloxicam Injection Alloxate An increased risk of bleeding Details Clopidogrel Melphalan Injection Alkeran An increased risk of bleeding Details Clopidogrel Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Clopidogrel Morphine Injection Astramorph® PF Reduced efficacy of clopidogrel Details Clopidogrel Nalbuphine Injection Nubain® Reduced efficacy of clopidogrel Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.