Clotrimazole Lozenge

Name: Clotrimazole Lozenge Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

35 interactions 186 cited references

Also sold as: Mycelex®

About Clotrimazole Lozenge

Clotrimazole lozenges are used to treat yeast infections of the mouth in adults and children 3 years of age and older. It can also be used to prevent yeast infections of the mouth in people at risk of these infections who are receiving certain treatments. Clotrimazole is in a class of antifungal medications called imid… Read the full Clotrimazole Lozenge drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Alfentanil Bedaquiline Colchicine Dihydroergotamine Doxorubicin Doxorubicin Hydrochloride Liposome

29 Major 6 Moderate

All (35) Major (29) Moderate (6)

Moderate

Clotrimazole Lozenge Artemether Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Clotrimazole Lozenge Dofetilide Tikosyn Increased dofetilide exposure Details Clotrimazole Lozenge Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Clotrimazole Lozenge Lumefantrine Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Clotrimazole Lozenge Sirolimus Felycin An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, fever, diarrhea) Details Clotrimazole Lozenge Trimetrexate Increased trimetrexate toxicity (bone marrow suppression, renal and hepatic dysfunction, and gastrointestinal ulceration) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.