Clotrimazole Topical

35 interactions 186 cited references
Also sold as: Cruex Antifungal Dermatin Jock-Eze Lotrimin Lotrimin® AF Athlete's Foot Cream Lotrimin® AF Jock Itch Cream Lotrimin® AF Ringworm Cream Lotrimin® Solution Trimazole
About Clotrimazole Topical

Topical clotrimazole is used to treat tinea corporis (ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the t… Read the full Clotrimazole Topical drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Alfentanil Bedaquiline Colchicine Dihydroergotamine Doxorubicin Doxorubicin Hydrochloride Liposome
29 Major 6 Moderate
All (35) Major (29) Moderate (6)

Major

Clotrimazole Topical Alfentanil Increased ALfentanil exposure and an increased risk of respiratory depression Details Clotrimazole Topical Bedaquiline Sirturo Increased bedaquiline exposure Details Clotrimazole Topical Colchicine Colcrys Increased colchicine exposure and an increased risk of colchicine-related toxicity Details Clotrimazole Topical Dihydroergotamine Brekiya Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Topical Doxorubicin Adriamycin Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Clotrimazole Topical Doxorubicin Hydrochloride Liposome Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Clotrimazole Topical Ergoloid Mesylates Alkergot® Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Topical Ergonovine Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Topical Ergotamine Ergomar Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Topical Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Clotrimazole Topical Haloperidol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Clotrimazole Topical Lemborexant Dayvigo Increased lemborexant exposure and an increased risk of lemborexant-related adverse reactions. Details Clotrimazole Topical Lisuride Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Topical Lomitapide Increased lomitapide exposure Details Clotrimazole Topical Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Clotrimazole Topical Meperidine Demerol Increased meperidine exposure and risk of increased or prolonged opioid effects Details Clotrimazole Topical Metergoline Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Topical Methylergonovine Methergine Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Topical Methysergide Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Topical Mifepristone Korlym Increased miFEPRIStone exposure Details Clotrimazole Topical Nicergoline Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Clotrimazole Topical Nifedipine Adalat® Increased NIFEdipine exposure Details Clotrimazole Topical Paclitaxel Abraxane Increased PACLitaxel exposure Details Clotrimazole Topical Paclitaxel Protein-Bound Increased PACLitaxel exposure Details Clotrimazole Topical Pimozide Increased pimozide exposure Details Clotrimazole Topical Roflumilast Daliresp Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Clotrimazole Topical Tacrolimus Astagraf Increased tacrolimus concentration and an increased risk of toxicity Details Clotrimazole Topical Tramadol ConZip Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Clotrimazole Topical Voriconazole Vfend Increased voriconazole exposure and an increased risk of voriconazole-related adverse reaction Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.