Clotrimazole Topical

Name: Clotrimazole Topical Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

35 interactions 186 cited references

Also sold as: Cruex Antifungal Dermatin Jock-Eze Lotrimin Lotrimin® AF Athlete's Foot Cream Lotrimin® AF Jock Itch Cream Lotrimin® AF Ringworm Cream Lotrimin® Solution Trimazole

About Clotrimazole Topical

Topical clotrimazole is used to treat tinea corporis (ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), and tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the t… Read the full Clotrimazole Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Alfentanil Bedaquiline Colchicine Dihydroergotamine Doxorubicin Doxorubicin Hydrochloride Liposome

29 Major 6 Moderate

All (35) Major (29) Moderate (6)

Moderate

Clotrimazole Topical Artemether Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Clotrimazole Topical Dofetilide Tikosyn Increased dofetilide exposure Details Clotrimazole Topical Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Clotrimazole Topical Lumefantrine Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Clotrimazole Topical Sirolimus Felycin An increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, fever, diarrhea) Details Clotrimazole Topical Trimetrexate Increased trimetrexate toxicity (bone marrow suppression, renal and hepatic dysfunction, and gastrointestinal ulceration) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.