Cloxacillin

18 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Demeclocycline Doxycycline Injection Eravacycline Injection Estradiol Estradiol Topical Estradiol Transdermal Patch
13 Major 5 Minor
All (18) Major (13) Minor (5)

Major

Cloxacillin Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Cloxacillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Cloxacillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Cloxacillin Estradiol Delestrogen Decreased contraceptive effectiveness Details Cloxacillin Estradiol Topical Divigel Decreased contraceptive effectiveness Details Cloxacillin Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Cloxacillin Hydroxychloroquine Plaquenil An increased risk of seizures Details Cloxacillin Levonorgestrel After banger Decreased contraceptive effectiveness Details Cloxacillin Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Cloxacillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Cloxacillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Cloxacillin Minocycline Amzeeq Decreased antibacterial effectiveness Details Cloxacillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details

Minor

Cloxacillin Amikacin Injection Amikin® Loss of aminoglycoside efficacy Details Cloxacillin Amikacin Oral Inhalation Arikayce Loss of aminoglycoside efficacy Details Cloxacillin Gentamicin Injection Garamycin® I.V. Loss of aminoglycoside efficacy Details Cloxacillin Gentamicin Ophthalmic Garamycin® Ophthalmic Loss of aminoglycoside efficacy Details Cloxacillin Gentamicin Topical Garamycin® Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.