Cocaine

19 interactions 4 explained in plain English
Also sold as: Goprelto Numbrino
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Granisetron Transdermal Patch Linezolid Injection Fentanyl Transdermal Patch Palonosetron Injection Morphine Injection
19 Major
All (19) Major (19)

Major

Cocaine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Cocaine Amitriptyline Elavil Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Cocaine Sertraline Explained An increased risk of serotonin syndrome Details Cocaine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Cocaine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Cocaine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Cocaine Dolasetron Anzemet Increased risk of serotonin syndrome Details Cocaine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Cocaine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Cocaine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Cocaine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Cocaine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Cocaine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Cocaine Hydroxychloroquine Plaquenil An increased risk of seizures Details Cocaine Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Cocaine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Cocaine Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Cocaine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Cocaine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.