Codeine

Contraindicated

Codeine Linezolid Injection Zyvox Increased risk of serotonin syndrome Details

Major

Codeine Abametapir Explained Increased exposure of CYP3A4 substrate Details Codeine Amitriptyline Elavil Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Codeine Sertraline Explained Increased risk of serotonin syndrome, increased codeine exposure and reduced active metabolite (morphine) exposure Details Codeine Buprenorphine Belbuca Explained Reduced analgesic effect and/or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome and an increased ris... Details Codeine Trospium / Xanomeline Cobenfy Explained An increased risk of paralytic ileus Details Codeine Aripiprazole Injection Abilify An increased risk of respiratory and CNS depression Details Codeine Asenapine Transdermal Patch Secuado An increased risk of respiratory and CNS depression Details Codeine Abiraterone Abirtega Increased codeine exposure and reduced active metabolite (morphine) exposure Details Codeine Aclidinium Oral Inhalation Tudorza An increased risk of paralytic ileus Details Codeine Atropine Ophthalmic Atropine Care 1% An increased risk of paralytic ileus Details Codeine Butorphanol Injection Butorphic Reduced analgesic effect and/or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome and an increased ris... Details Codeine Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect and/or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome and an increased ris... Details Codeine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Codeine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Codeine Clopidogrel Plavix Reduced efficacy of clopidogrel Details Codeine Cyclopentolate Ophthalmic Akpentolate® An increased risk of paralytic ileus Details Codeine Cyclosporine Injection Atopica Increased codeine and morphine exposure Details Codeine Cyclosporine Ophthalmic Cequa Increased codeine and morphine exposure Details Codeine Dexamethasone Injection Decadron Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Codeine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Codeine Diazepam Nasal Spray Valtoco An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Codeine Diazepam Rectal Diastat An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Codeine Diphenhydramine Injection Banophen Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Codeine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Codeine Dolasetron Anzemet Increased risk of serotonin syndrome Details Codeine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Codeine Esketamine Nasal Spray Spravato Increased risk of sedation Details Codeine Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Codeine Furosemide Injection Disal Reduced diuretic efficacy Details Codeine Glycopyrronium Topical Cuvposa® An increased risk of paralytic ileus Details Codeine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Codeine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Codeine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Codeine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Codeine Ipratropium Nasal Spray Atrovent Nasal Spray® An increased risk of paralytic ileus Details Codeine Ipratropium Oral Inhalation Atrovent® HFA An increased risk of paralytic ileus Details Codeine Ketoconazole Topical Extina® Foam Increased codeine and morphine exposure Details Codeine Lacosamide Injection Motpoly An increased risk of CNS depression Details Codeine Lenacapavir Injection Sunlenca Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-mediated adverse reactions Details