Cortisone

21 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Lenacapavir Oral Aspirin Levofloxacin Injection Ofloxacin Gatifloxacin Ophthalmic
1 Contraindicated 16 Major 4 Moderate
All (21) Contraindicated (1) Major (16) Moderate (4)

Contraindicated

Cortisone Desmopressin Nasal Concentraid® Increased risk of severe hyponatremia Details

Major

Cortisone Aldesleukin Proleukin Reduced antitumor effectiveness Details Cortisone Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Cortisone Aspirin Rectal Aspirin An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Cortisone Besifloxacin Ophthalmic Besivance An increased risk of tendon rupture Details Cortisone Gatifloxacin Ophthalmic Zymar® An increased risk of tendon rupture Details Cortisone Gemifloxacin Factive An increased risk of tendon rupture Details Cortisone Lenacapavir Injection Sunlenca Increased CYP3A substrate/systemic corticosteroid exposure and an increased risk of Cushing's syndrome and adrenal suppression Details Cortisone Lenacapavir Oral Sunlenca Increased CYP3A substrate/systemic corticosteroid exposure and an increased risk of Cushing's syndrome and adrenal suppression Details Cortisone Levofloxacin Levaquin An increased risk of tendon rupture Details Cortisone Levofloxacin Injection Levaquin An increased risk of tendon rupture Details Cortisone Moxifloxacin Avelox An increased risk of tendon rupture Details Cortisone Moxifloxacin Injection Avelox An increased risk of tendon rupture Details Cortisone Moxifloxacin Ophthalmic Moxeza® An increased risk of tendon rupture Details Cortisone Ofloxacin Floxin® An increased risk of tendon rupture Details Cortisone Ofloxacin Ophthalmic Ocuflox An increased risk of tendon rupture Details Cortisone Ofloxacin Otic Floxin® Otic An increased risk of tendon rupture Details

Moderate

Cortisone Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Cortisone Furosemide Injection Disal Hypokalemia Details Cortisone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Cortisone Olodaterol Oral Inhalation Striverdi An increased risk of hypokalemia Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.