Cyclopenthiazide

44 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Morphine Injection Naproxen Hydromorphone Rectal Aspirin Fentanyl Transdermal Patch Meclofenamate

32 Major 12 Moderate

All (44) Major (32) Moderate (12)

Major

Cyclopenthiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Cyclopenthiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Cyclopenthiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Cyclopenthiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Cyclopenthiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Cyclopenthiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Cyclopenthiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Cyclopenthiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Cyclopenthiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Cyclopenthiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Cyclopenthiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Cyclopenthiazide Lisinopril Prinivil Explained Reduction of blood pressure Details Cyclopenthiazide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Cyclopenthiazide Benazepril Lotensin Reduction of blood pressure Details Cyclopenthiazide Captopril Capoten® Reduction of blood pressure Details Cyclopenthiazide Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Cyclopenthiazide Dofetilide Tikosyn An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Cyclopenthiazide Enalapril Epaned Reduction of blood pressure Details Cyclopenthiazide Fosinopril Monopril® Reduction of blood pressure Details

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