Cyclophosphamide Injection and Eslicarbazepine Acetate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Eslicarbazepine Acetate
Cyclophosphamide Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of CYP2C19 substrates
Interaction Deep Dive
Concurrent administration of eslicarbazepine acetate (a CYP2C19 inhibitor) with a CYP2C19 substrate may increase the exposure of the CYP2C19 substrate1. If coadministering, use caution and monitor the patient closely.
Why it happens (mechanism)
Inhibition of CYP2C19-mediated metabolism by eslicarbazepine acetate
Common questions
Can I take Cyclophosphamide Injection and Eslicarbazepine Acetate together?
Increased exposure of CYP2C19 substrates Always confirm with your pharmacist or prescriber before making any change.
How serious is the Cyclophosphamide Injection and Eslicarbazepine Acetate interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Cyclophosphamide Injection or Eslicarbazepine Acetate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: APTIOM(R) oral tablets, eslicarbazepine acetate oral tablets. Sunovion Pharmaceuticals Inc (per manufacturer), Marlborough, MA, 2017. DailyMed
Keep reading about Eslicarbazepine Acetate
Keep reading about Cyclophosphamide Injection
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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