Cyclophosphamide Injection

84 interactions 1,015 cited references

Also sold as: Cytoxan® Injection Frindovyx Neosar® Injection

About Cyclophosphamide Injection

Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that fir… Read the full Cyclophosphamide Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live

9 Contraindicated 44 Major 30 Moderate 1 Minor

All (84) Contraindicated (9) Major (44) Moderate (30) Minor (1)

Contraindicated

Cyclophosphamide Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Cyclophosphamide Injection Abametapir Increased exposure of CYP2B6 substrates Details Cyclophosphamide Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Amprenavir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Injection Articaine An increased risk of methemoglobinemia Details Cyclophosphamide Injection Atazanavir Reyataz Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Injection Boceprevir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Injection Cannabidiol Epidiolex Altered (increased or reduced) CYP2B6 substrates exposure Details Cyclophosphamide Injection Carbamazepine Carbatrol Increased risk of cycloPHOSphamide toxicity Details Cyclophosphamide Injection Ceritinib Zykadia Decreased cyclophosphamide efficacy Details Cyclophosphamide Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Cobicistat Tybost Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Injection Cyclosporine Atopica Decreased serum cycloSPORINE concentration Details Cyclophosphamide Injection Darunavir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Injection Doxorubicin Adriamycin Increased risk of cardiomyopathy Details Cyclophosphamide Injection Doxorubicin Hydrochloride Liposome Increased risk of cardiomyopathy Details Cyclophosphamide Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Eslicarbazepine Acetate Aptiom Increased exposure of CYP2C19 substrates Details Cyclophosphamide Injection Etanercept Higher incidence of developing non-cutaneous solid malignancies Details Cyclophosphamide Injection Fexinidazole Decreased plasma concentrations of CYP2B6 substrate Details Cyclophosphamide Injection Fosamprenavir Lexiva Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Injection Fosphenytoin Cerebyx Increased plasma concentrations of the active metabolite of cyclophosphamide and an increased risk of toxicity Details Cyclophosphamide Injection Idarubicin Idamycin Increased risk of cardiotoxicity Details Cyclophosphamide Injection Indinavir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Cyclophosphamide Injection Lemborexant Dayvigo Reduced CYP2B6 substrates exposure and reduced efficacy of CYP2B6 substrates Details Cyclophosphamide Injection Lidocaine Akten An increased risk of methemoglobinemia Details Cyclophosphamide Injection Lopinavir Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Injection Nelfinavir Viracept Increased risk of chemotherapy-induced mucositis, neutropenia, and infection Details Cyclophosphamide Injection Nevirapine Viramune Reduced cycloPHOSphamide exposure Details Cyclophosphamide Injection Nilotinib Decreased cyclophosphamide efficacy Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.