Cyclosporine Ophthalmic

545 interactions 1,631 cited references
Also sold as: Cequa Cequa® Restasis® Vevye
About Cyclosporine Ophthalmic

Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is in a class of medications called immunomodulators. It works by decreasing swelling in the eye to allow for tear production. Read the full Cyclosporine Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Cyclosporine Ophthalmic Bosentan Reduced cycloSPORINE exposure and increased bosentan exposure Details Cyclosporine Ophthalmic Colchicine Colcrys Increased colchicine and cycloSPORINE exposure Details Cyclosporine Ophthalmic Dronedarone Multaq Increased dronedarone plasma concentrations Details Cyclosporine Ophthalmic Elagolix Orilissa Increased elagolix exposure and an increased risk of elagolix-related adverse reactions Details Cyclosporine Ophthalmic Ensitrelvir Increased CYP3A/P-gp substrate exposure and an increased risk of adverse reactions Details Cyclosporine Ophthalmic Ezetimibe Zetia Increased ezetimibe and cycloSPORINE exposure and an increased risk of ezetimibe and cycloSPORINE-related adverse effects Details Cyclosporine Ophthalmic Grazoprevir Increased grazoprevir exposure and an increased risk of ALT elevation Details Cyclosporine Ophthalmic Lercanidipine Increased cyclosporine and lercanidipine exposure Details Cyclosporine Ophthalmic Levoketoconazole Recorlev Increased cycloSPORINE exposure, an increased risk of hepatotoxicity and a drug-induced liver injury Details Cyclosporine Ophthalmic Mifepristone Korlym Increased cycloSPORINE exposure and an increased miFEPRIStone exposure Details Cyclosporine Ophthalmic Pitavastatin Livalo Increased pitavastatin exposure and increased risk of myopathy and rhabdomyolysis Details Cyclosporine Ophthalmic Simvastatin Flolipid An increased risk of myopathy or rhabdomyolysis Details Cyclosporine Ophthalmic Sitaxsentan Increased sitaxsentan plasma concentrations Details

Major

Cyclosporine Ophthalmic Abametapir Increased exposure of CYP3A4 substrate Details Cyclosporine Ophthalmic Abrocitinib Cibinqo Increased exposure of P-glycoprotein substrate Details Cyclosporine Ophthalmic Acalabrutinib Calquence Increased acalabrutinib exposure and increased risk of toxicity Details Cyclosporine Ophthalmic Aceclofenac An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Acemetacin An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Adagrasib Krazati Increased exposure to CYP3A/P-gp substrates Details Cyclosporine Ophthalmic Adalimumab Altered cycloSPORINE exposure Details Cyclosporine Ophthalmic Adenovirus Vaccine Type 4, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Adenovirus Vaccine Type 7, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Afatinib Gilotrif Increased exposure of afatinib Details Cyclosporine Ophthalmic Alefacept Decreased cycloSPORINE plasma concentrations Details Cyclosporine Ophthalmic Alfalfa Reduced immunosuppressive drug effectiveness and acute transplant rejection Details Cyclosporine Ophthalmic Alfentanil Increased ALfentanil exposure and an increased risk of respiratory depression Details Cyclosporine Ophthalmic Aliskiren Tekturna Increased aliskiren exposure and plasma concentrations Details Cyclosporine Ophthalmic Alogliptin Nesina Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Cyclosporine Ophthalmic Alprazolam Xanax Increased ALPRAZolam exposure and an increased risk of ALPRAZolam-related adverse reactions Details Cyclosporine Ophthalmic Ambrisentan Letairis Increased ambrisentan exposure Details Cyclosporine Ophthalmic Amifampridine Increased risk of seizures Details Cyclosporine Ophthalmic Amiloride An increased risk of hyperkalemia Details Cyclosporine Ophthalmic Amlodipine Amvaz® Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Amphotericin B An increased risk of renal dysfunction Details Cyclosporine Ophthalmic Amprenavir Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Amtolmetin Guacil An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Apalutamide Erleada Reduced cycloSPORINE exposure Details Cyclosporine Ophthalmic Apazone Increased risk of renal dysfunction Details Cyclosporine Ophthalmic Aprepitant Aponvie Increased cycloSPORINE exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.