Cyclosporine Ophthalmic

545 interactions 1,631 cited references
Also sold as: Cequa Cequa® Restasis® Vevye
About Cyclosporine Ophthalmic

Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is in a class of medications called immunomodulators. It works by decreasing swelling in the eye to allow for tear production. Read the full Cyclosporine Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Cyclosporine Ophthalmic Abametapir Increased exposure of CYP3A4 substrate Details Cyclosporine Ophthalmic Abrocitinib Cibinqo Increased exposure of P-glycoprotein substrate Details Cyclosporine Ophthalmic Acalabrutinib Calquence Increased acalabrutinib exposure and increased risk of toxicity Details Cyclosporine Ophthalmic Aceclofenac An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Acemetacin An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Adagrasib Krazati Increased exposure to CYP3A/P-gp substrates Details Cyclosporine Ophthalmic Adalimumab Altered cycloSPORINE exposure Details Cyclosporine Ophthalmic Adenovirus Vaccine Type 4, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Adenovirus Vaccine Type 7, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Afatinib Gilotrif Increased exposure of afatinib Details Cyclosporine Ophthalmic Alefacept Decreased cycloSPORINE plasma concentrations Details Cyclosporine Ophthalmic Alfalfa Reduced immunosuppressive drug effectiveness and acute transplant rejection Details Cyclosporine Ophthalmic Alfentanil Increased ALfentanil exposure and an increased risk of respiratory depression Details Cyclosporine Ophthalmic Aliskiren Tekturna Increased aliskiren exposure and plasma concentrations Details Cyclosporine Ophthalmic Alogliptin Nesina Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Cyclosporine Ophthalmic Alprazolam Xanax Increased ALPRAZolam exposure and an increased risk of ALPRAZolam-related adverse reactions Details Cyclosporine Ophthalmic Ambrisentan Letairis Increased ambrisentan exposure Details Cyclosporine Ophthalmic Amifampridine Increased risk of seizures Details Cyclosporine Ophthalmic Amiloride An increased risk of hyperkalemia Details Cyclosporine Ophthalmic Amlodipine Amvaz® Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Amphotericin B An increased risk of renal dysfunction Details Cyclosporine Ophthalmic Amprenavir Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Amtolmetin Guacil An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Apalutamide Erleada Reduced cycloSPORINE exposure Details Cyclosporine Ophthalmic Apazone Increased risk of renal dysfunction Details Cyclosporine Ophthalmic Aprepitant Aponvie Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Artemether Increased artemether/lumefantrine exposure, an increased risk of QT prolongation, reduced CYP3A4 substrate exposure and reduced ef... Details Cyclosporine Ophthalmic Asciminib Scemblix Increased exposure to CYP3A4/P-gp substrates and increased risk of CYP3A4/P-gp substrates-related adverse effects Details Cyclosporine Ophthalmic Aspirin Acuprin® An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Asunaprevir Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Atogepant Qulipta Increased atogepant exposure Details Cyclosporine Ophthalmic Atorvastatin Atorvaliq Increased atorvastatin exposure, an increased risk of myopathy or rhabdomyolysis and an increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Atrasentan Increased atrasentan exposure and an increased risk of atrasentan-related adverse reactions Details Cyclosporine Ophthalmic Avacopan Tavneos Increased exposure to CYP3A4 substrate Details Cyclosporine Ophthalmic Azathioprine Azasan Reduced cycloSPORINE exposure and an increased risk of hepatotoxicity Details Cyclosporine Ophthalmic Azilsartan Edarbi An increased risk of hyperkalemia Details Cyclosporine Ophthalmic Azilsartan Medoxomil Edarbi An increased risk of hyperkalemia Details Cyclosporine Ophthalmic Azithromycin AzaSite Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Bacillus Of Calmette And Guerin Vaccine, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.