Cyclosporine Ophthalmic

545 interactions 1,631 cited references
Also sold as: Cequa Cequa® Restasis® Vevye
About Cyclosporine Ophthalmic

Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is in a class of medications called immunomodulators. It works by decreasing swelling in the eye to allow for tear production. Read the full Cyclosporine Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Cyclosporine Ophthalmic Bosentan Reduced cycloSPORINE exposure and increased bosentan exposure Details Cyclosporine Ophthalmic Colchicine Colcrys Increased colchicine and cycloSPORINE exposure Details Cyclosporine Ophthalmic Dronedarone Multaq Increased dronedarone plasma concentrations Details Cyclosporine Ophthalmic Elagolix Orilissa Increased elagolix exposure and an increased risk of elagolix-related adverse reactions Details Cyclosporine Ophthalmic Ensitrelvir Increased CYP3A/P-gp substrate exposure and an increased risk of adverse reactions Details Cyclosporine Ophthalmic Ezetimibe Zetia Increased ezetimibe and cycloSPORINE exposure and an increased risk of ezetimibe and cycloSPORINE-related adverse effects Details Cyclosporine Ophthalmic Grazoprevir Increased grazoprevir exposure and an increased risk of ALT elevation Details Cyclosporine Ophthalmic Lercanidipine Increased cyclosporine and lercanidipine exposure Details Cyclosporine Ophthalmic Levoketoconazole Recorlev Increased cycloSPORINE exposure, an increased risk of hepatotoxicity and a drug-induced liver injury Details Cyclosporine Ophthalmic Mifepristone Korlym Increased cycloSPORINE exposure and an increased miFEPRIStone exposure Details Cyclosporine Ophthalmic Pitavastatin Livalo Increased pitavastatin exposure and increased risk of myopathy and rhabdomyolysis Details Cyclosporine Ophthalmic Simvastatin Flolipid An increased risk of myopathy or rhabdomyolysis Details Cyclosporine Ophthalmic Sitaxsentan Increased sitaxsentan plasma concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.