Cyclosporine Ophthalmic

545 interactions 1,631 cited references
Also sold as: Cequa Cequa® Restasis® Vevye
About Cyclosporine Ophthalmic

Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is in a class of medications called immunomodulators. It works by decreasing swelling in the eye to allow for tear production. Read the full Cyclosporine Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Cyclosporine Ophthalmic Rosuvastatin Crestor Increased rosuvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Cyclosporine Ophthalmic Rotavirus Vaccine, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Rubella Virus Vaccine, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Rucaparib Rubraca Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Salicylic Acid An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Salsalate Disalcid An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Saquinavir Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Sarecycline Seysara Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Schisandra Sphenanthera Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Selpercatinib Retevmo Increased exposure of selpercatinib and cycloSPORINE and increased risk of adverse effects Details Cyclosporine Ophthalmic Sevabertinib Hyrnuo Increased) CYP3A4/P-gp substrate with NTI exposure and an increased risk of CYP3A4/P-gp substrate with NTI-related adverse reactio... Details Cyclosporine Ophthalmic Silodosin Rapaflo Increased silodosin concentration Details Cyclosporine Ophthalmic Simeprevir Olysio® Increased exposure of cycloSPORINE Details Cyclosporine Ophthalmic Sirolimus Felycin Increased sirolimus exposure and an increased risk of sirolimus toxicity (anemia, leukopenia, thrombocytopenia, hypokalemia, diarr... Details Cyclosporine Ophthalmic Sirolimus Protein-Bound Increased concentrations of sirolimus Details Cyclosporine Ophthalmic Smallpox Monkeypox Vaccine An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Sodium Salicylate An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Sofosbuvir Sovaldi Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Sonidegib Odomzo Increased sonidegib exposure Details Cyclosporine Ophthalmic Sotorasib Lumakras Reduced exposure to CYP3A substrate and an increased risk of therapeutic failure Details Cyclosporine Ophthalmic Spirapril Acute renal dysfunction and an increased risk of hyperkalemia Details Cyclosporine Ophthalmic Spironolactone Aldactone An increased risk of hyperkalemia and an increased cycloSPORINE exposure Details Cyclosporine Ophthalmic St John's Wort Reduced cycloSPORINE exposure, reduced cycloSPORINE efficacy, acute transplant rejection and graft loss Details Cyclosporine Ophthalmic Sufentanil Dsuvia Increased SUFentanil exposure and an increased risk of respiratory depression Details Cyclosporine Ophthalmic Sulfamethoxazole Sustain Increased nephrotoxicity and an increased risk of renal dysfunction Details Cyclosporine Ophthalmic Sulfinpyrazone Reduced cycloSPORINE exposure and an increased risk of organ rejection Details Cyclosporine Ophthalmic Sulindac Clinoril® An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Sunvozertinib Zegfrovy Increased P-gp substrates with NTI exposure and increased risk of P-gp substrates with NTI-related adverse effects Details Cyclosporine Ophthalmic Suvorexant Belsomra Increased cycloSPORINE exposure and increased suvorexant exposure Details Cyclosporine Ophthalmic Suzetrigine Journavx Reduced sensitive CYP3A substrate with NTI exposure and reduced efficacy of sensitive CYP3A substrate with NTI Details Cyclosporine Ophthalmic Tacrolimus Astagraf Increased tacrolimus exposure and an increased risk of nephrotoxicity Details Cyclosporine Ophthalmic Talazoparib Talzenna Increased talazoparib exposure and an increased risk of talazoparib-related adverse reactions Details Cyclosporine Ophthalmic Taurursodiol Serious toxicities or loss of efficacy Details Cyclosporine Ophthalmic Teicoplanin Increased risk of nephrotoxicity and/or ototoxicity Details Cyclosporine Ophthalmic Telaprevir Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Telithromycin Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Telmisartan Micardis An increased risk of hyperkalemia and an increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Telotristat Ethyl Xermelo Reduced cycloSPORINE exposure Details Cyclosporine Ophthalmic Tenoxicam An increased risk of cycloSPORINE nephrotoxicity Details Cyclosporine Ophthalmic Tepotinib Tepmetko Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.