Cyclosporine Ophthalmic

545 interactions 1,631 cited references

Also sold as: Cequa Cequa® Restasis® Vevye

About Cyclosporine Ophthalmic

Ophthalmic cyclosporine is used to increase tear production in people with dry eye disease. Cyclosporine is in a class of medications called immunomodulators. It works by decreasing swelling in the eye to allow for tear production. Read the full Cyclosporine Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dronedarone Elagolix Ensitrelvir Ezetimibe Sitaxsentan Simvastatin

13 Contraindicated 439 Major 92 Moderate 1 Minor

All (545) Contraindicated (13) Major (439) Moderate (92) Minor (1)

Major

Cyclosporine Ophthalmic Vonoprazan Voquezna Increased CYP3A substrates exposure Details Cyclosporine Ophthalmic Vorapaxar Zontivity Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Vorasidenib Voranigo Reduced CYP3A substrate with NTI exposure and reduced efficacy of CYP3A substrate with NTI Details Cyclosporine Ophthalmic Voriconazole Vfend Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Voxelotor Oxbryta Increased exposure of sensitive CYP3A4 substrates Details Cyclosporine Ophthalmic Voxilaprevir Increased voxilaprevir plasma concentrations Details Cyclosporine Ophthalmic Warfarin Coumadin Increased warfarin exposure, increased INR and reduced efficacy of cycloSPORINE and warfarin Details Cyclosporine Ophthalmic Yellow Fever Vaccine Stamaril An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details Cyclosporine Ophthalmic Zanubrutinib Brukinsa Increased zanubrutinib exposure, an increased risk of zanubrutinib toxicity and an increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Zavegepant Increased zavegepant exposure Details Cyclosporine Ophthalmic Zolpidem Ambien Increased zolpidem exposure Details Cyclosporine Ophthalmic Zoster Vaccine, Live An inadequate immunological response to the vaccine, increased risk of disseminated infection with live vaccines and reduced effic... Details

Moderate

Cyclosporine Ophthalmic Abemaciclib Verzenio Increased abemaciclib plasma concentration Details Cyclosporine Ophthalmic Acetazolamide Diamox® Sequels® An increased risk of cycloSPORINE toxicity Details Cyclosporine Ophthalmic Alacepril Acute renal failure Details Cyclosporine Ophthalmic Alfuzosin UroXatral An increase in alfuzosin exposure Details Cyclosporine Ophthalmic Allopurinol Aloprim Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Amikacin Renal dysfunction or nephrotoxicity Details Cyclosporine Ophthalmic Amiodarone Nexterone Increased plasma levels of cycloSPORINE Details Cyclosporine Ophthalmic Amphotericin B Cholesteryl Sulfate Complex Renal dysfunction Details Cyclosporine Ophthalmic Amphotericin B Lipid Complex An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Amphotericin B Liposome An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Armodafinil Nuvigil Decreased cycloSPORINE effectiveness Details Cyclosporine Ophthalmic Atazanavir Reyataz Increased cycloSPORINE exposure Details Cyclosporine Ophthalmic Autumn Crocus Gastrointestinal dysfunction, hepatonephropathy, and neuromyopathy Details Cyclosporine Ophthalmic Avanafil Stendra Increased avanafil exposure Details Cyclosporine Ophthalmic Cannabis Increased cannabis exposure Details Cyclosporine Ophthalmic Carvedilol Coreg An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Ceftriaxone An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Chloramphenicol An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Chloroquine Aralen® An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Cilazapril Acute renal failure Details Cyclosporine Ophthalmic Cisapride Propulsid® An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Clindamycin ANTIROBE Decreased cycloSPORINE bioavailability Details Cyclosporine Ophthalmic Clonidine Duraclon An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Colesevelam Welchol Decreased cycloSPORINE exposure and plasma concentrations Details Cyclosporine Ophthalmic Dalfopristin Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Danazol Danocrine® Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Cyclosporine Ophthalmic Dibekacin Renal dysfunction or nephrotoxicity Details Cyclosporine Ophthalmic Dirithromycin An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.